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Salvinorin B ethoxymethyl ether (2-''O''-ethoxymethylsalvinorin B, ''symmetry'') is a semi-synthetic analogue of the natural product salvinorin A, with a longer duration of action of around 3 hours (compared to less than 30 minutes for salvinorin A), and increased affinity and intrinsic activity at the κ-opioid receptor. Like the related compound herkinorin, 2-ethoxymethyl salvinorin B is made from salvinorin B, which is most conveniently made from salvinorin A by deacetylation, as while both salvinorin A and salvinorin B are found in the plant ''Salvia divinorum'', salvinorin A is present in larger quantities. Salvinorin B ethoxymethyl ether has a Ki of 0.32 nM at the κ-opioid receptor, and around 3,000 times selectivity over the μ- and δ-opioid receptors, making it one of the most potent and selective kappa agonists yet discovered. In animal studies it fully substituted for salvinorin A and the synthetic kappa agonist U-69593, and was active at doses as low as 0.005 mg/kg. Human bioassays found the compound to be active at 50 μg.〔(First Look at a New Psychoactive Drug:Symmetry (salvinorin B ethoxymethyl ether). ''The Entheogen Review''. 2008;16(4):136-45. )〕 == See also == * 2-Methoxymethyl salvinorin B * Herkinorin * Salvinorin A 抄文引用元・出典: フリー百科事典『 ウィキペディア（Wikipedia）』 ■ウィキペディアで「Salvinorin B ethoxymethyl ether」の詳細全文を読む スポンサード リンク
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